The CoagulopathyTrials Register is compiled from database searches (MEDLINE and CENTRAL) and the hand searching of journals (British Journal of Haematology and Haemophilia) and conference abstracts (European Haematology Association, American Society of Hematology, British Society for Haematology, Congress Of The World Federation of Haemophilia, International Society on Thrombosis and Haemostasis, European Association for Haemophilia and Allied Disorders, Hemostasis and Thrombosis Research Society). Details given below.
Database searching
MEDLINE - searched on Ovid, from 1966 to 1994, on SilverPlatter CD‐Rom, from 1994 to 2002 and Ovid from 2003 to the present. The following search strategy for Ovid MEDLINE is being used:
#1 randomized controlled trial.pt.
#2 controlled clinical trial.pt.
#3 randomized.ab.
#4 placebo.ab.
#5 drug therapy.fs.
#6 randomly.ab.
#7 trial.ab.
#8 groups.ab.
#9 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8
#10 animals.sh. not (humans.sh. and animals.sh.)
#11 9 not 10
#12 exp Coagulation Protein Disorders/
#13 exp Blood Coagulation Disorders/
#14 (congenital or inherit$ or hereditary).tw.
#15 13 and 14
#16 (hemophili$ or haemophili$).tw.
#17 afibrinogen$.tw. and 14
#18 hypofibrinogen$.tw. and 14
#19 dysfibrinogen$.tw. and 14
#20 christmas disease.tw.
#21 factor v defici$.tw.
#22 factor vii defici$.tw.
#23 factor viii defici$.tw.
#24 factor ix defici$.tw.
#25 factor x defici$.tw.
#26 factor xi defici$.tw.
#27 factor xii defici$.tw.
#28 factor xiii defici$.tw.
#29 hypoprothrombin$.tw. and 14
#30 von willebrand$ disease.tw.
#31 aspirin‐like defect.tw.
#32 coagulation disorder$.tw. and 14
#33 12 or (or/15‐32)
#34 11 and¬33
Lines #12 to #33 identify records relating to coagulopathies; lines #1 to #11 reflect the Cochrane Highly Sensitive Search Strategy for RCTs: sensitivity‐maximising version [2008 revision] and line #34 combines these components together to identify RCTs/CCTs on coagulopathies.
CENTRAL - searched on each new issue of the Cochrane Library.
#1 AFIBRINOGENEMIA
#2 FACTOR VII DEFICIENCY
#3 FACTOR XI DEFICIENCY
#4 FACTOR XII DEFICIENCY
#5 FACTOR XIII DEFICIENCY
#6 HEMOPHILIA A
#7 HEMOPHILIA B
#8 FACTOR V DEFICIENCY
#9 FACTOR X DEFICIENCY
#10 VON WILLEBRAND DISEASE
#11 HYPOPROTHROMBINEMIAS
#12 (congenital or inherit* or hereditary)
#13 (#11 and #12)
#14 BLOOD COAGULATION DISORDERS
#15 (#14 and #12)
#16 (afibrinogen* and #12)
#17 (hypofibrinogen* and #12)
#18 (dysfibrinogen* and #12)
#19 (chistmas next disease)
#20 (factor next ix next defici*)
#21 (factor next vii next defici*)
#22 (factor next xi next defici*)
#23 (factor next xii next defici*)
#24 (factor next xiii next defici*)
#25 (factor next v next defici*)
#26 (factor next x next defici*)
#27 (factor next viii next defici*)
#28 (hemophili* or haemophili*)
#29 (von next willebrand* next disease)
#30 (hypoprothrombin* and #12)
#31 (aspirin next like next defect)
#32 (coagulation next disorder*)
#33 (#32 and #12)
#34 (#1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or #13 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24 or #25 or #26 or #27 or #28 or #29 or #30 or #31 or #33)
#35 (#34 and (not sr‐cf))
Lines #1 to #34 identify records relating to coagulopathies. Line #35 identifies records which are not already on our coagulopathies register. Search terms shown in capitals are MeSH terms.
Hand searching
Journals
British Journal of Haematology Haemophilia
(1995 to 1996; Vol 105 Suppl 1 (1999); 2000) (1995 to 2018)
Conferences
European Hematology Association
(Searched abstracts on CD‐Rom) (NB. Searched only for RCT/CCTs relevant to the scope of the Group)
2nd Congress of the European Hematology Association; 1996 May 29‐June 1; Paris
3rd Congress of the European Hematology Association; 1998 July 4‐8; Amsterdam (Combined with the 27th Congress of the International Society of Haematology)
4th Congress of the European Hematology Association; 1999 June 9‐12; Barcelona
5th Congress of the European Hematology Association; 2000 June 25‐28; Birmingham
6th Congress of the European Hematology Association; 2001 June 21‐24; Frankfurt, Germany (searched online)
7th Congress of the European Hematology Association; 2002 June 6‐9; Florence, Italy (searched online)
8th Congress of the European Hematology Association; 2003 June 12‐15; Lyon, France (searched online)
9th Congress of the European Hematology Association; 2004 June 10‐13; Geneva, Switzerland (searched online)
10th Congress of the European Hematology Association; 2005 June 2‐5; Stockholm, Sweden (searched online)
11th Congress of the European Hematology Association; 2006 June 15‐18; Amsterdam, Netherlands (searched online)
12th Congress of the European Hematology Association; 2007 June 7‐10; Vienna, Austria (Haematologica 2007, Vol. 92, Suppl 1)
13th Congress of the European Hematology Association; 2008 Jun 12‐15; Copenhagen, Denmark (Haematologica 2008, Vol. 93, Suppl 1)
14th Congress of the European Hematology Association; 2009 Jun 4‐7; Berlin, Germany (searched online)
15th Congress of the European Hematology Association; 2010 Jun 10‐13; Barcelona, Spain (Haematologica 2010, Vol. 95, Suppl 2)
16th Congress of the European Hematology Association; 2011 June 9‐12; London, UK (searched online)
17th Congress of the European Hematology Association; 2012 Jun 14‐17; Amsterdam, The Netherlands (Haematologica 2012, Vol 97, Suppl 1)
18th Congress of the European Hematology Association; 2013 June 13‐16; Stockholm, Sweden (searched online)
19th Congress of the European Hematology Association; 2014 June 12‐15; Milan, Italy (searched online)
20th Congress of the European Hematology Association; 2015 June 11-14; Vienna, Austria (Haematologica 2015, Vol 100, Suppl 1)
21st Congress of the European Hematology Association; 2016 June 9-12; Copenhagen, Denmark (Haematologica 2016, Vol 101, Suppl 1)
22nd Congress of the European Hematology Association; 2017 June 22-25; Madrid, Spain (Haematologica 2017, Vol 102, Suppl 2)
23rd Congress of the European Hematology Association; June 14-17 Stockholm, Sweden (searched online)
American Society of Hematology
(Searched abstracts on CD‐Rom) (NB. Searched only for RCT/CCTs relevant to the scope of the Group)
Abstracts of the 37th Annual American Society of Hematology Meeting; 1995 Dec 1‐5; Seattle, Washington (Blood 1995, Vol. 86, No. 10, Suppl. 1)
Abstracts of the American Society of Hematology, 38th Annual Meeting; 1996 Dec 6‐10; Orlando, Florida (Blood 1996, Vol. 88, No. 10, Suppl. 1)
Abstracts of the American Society of Hematology, 39th Annual Meeting; 1997 Dec 5‐9; San Diego, California (Blood 1997, Vol. 90, No. 10, Suppl. 1)
Abstracts of the American Society of Hematology, 40th Annual Meeting; 1998 Dec 4‐8; Miami Beach, Florida (Blood 1998, Vol. 92, No. 10, Suppl. 1)
Abstracts of the American Society of Hematology, 41st Annual Meeting, 1999 Dec 3‐7; New Orleans, Louisianna (Blood 1999, Vol. 94, No. 10, Suppl. 1)
Abstracts of the 42nd Annual Meeting of the American Society of Hematology, 2000 Dec 1‐5; San Francisco, California (Blood 2000, Vol. 96, No. 11)
Abstracts of the 43rd Annual Meeting of the American Society of Hematology, 2001 Dec 7‐11, Orlando, Florida (Blood 2001, Vol. 98, No 11)
Abstracts of the 44th Annual Meeting of the American Society of Hematology, 2002 Dec 6‐10; Philadelphia, Pennsylvania (Blood 2002, Vol. 100, No 11)
Abstracts of the 45th Annual Meeting of the American Society of Hematology, 2003 Dec 6‐9; San Diego, California (Blood 2003, Vol. 102, No 11)
Abstracts of the 46th Annual Meeting of the American Society of Hematology, 2004 Dec 4‐7; San Diego, California (Searched CD‐Rom)
Abstracts of the 47th Annual Meeting of the American Society of Hematology, 2005 Dec 10‐13; (Blood 2005, Vol. 106, No 11)
Abstracts of the 48th Annual Meeting of the American Society of Hematology, 2006 Dec 9‐12; Orlando, Florida (Blood 2006, Vol. 108, No 11)
Abstracts of the 49th Annual Meeting of the American Society of Hematology, 2007 Dec 8‐11; Atlanta, Georgia (Blood 2007, Vol. 110, No 11)
Abstracts of the 50th Annual Meeting of the American Society of Hematology, 2008 Dec 6‐9; San Francisco, California (Blood, 2008, 112, No 11)
Abstracts of the 51st Annual Meeting of the American Society of Hematology, 2009 Dec 5‐8; New Orleans, Louisiana (Blood, 2009, 114, No 22)
Abstracts of the 52nd Annual Meeting of the American Society of Hematology; 2010 Dec 4‐7; Orlando, Florida
Abstracts of the 53rd Annual Meeting of the American Society of Hematology; 2011 Dec 10‐13; San Diego, California (Blood 2011, Vol. 118, No 21)
Abstracts of the 54th Annual Meeting of the American Society of Hematology; 2012 Dec 8‐11; Atlanta, Georgia (Blood 2012, Vol. 120, No 21)
Abstracts of the 55th Annual Meeting of the American Society of Hematology; 2013 Dec 7‐10; New Orleans, Louisiana (searched online at http://www.hematology.org/Annual‐Meeting/Archive.aspx)
Abstracts of the 56th Annual Meeting of the American Society of Hematology; 2014 Dec 6‐9; San Francisco, California (searched online at http://www.hematology.org/Annual‐Meeting/Archive.aspx)
Abstracts of the 57th Annual Meeting of the American Society of Hematology; 2015 Dec 5‐8; Orlando, Florida (searched online at https://ash.confex.com/ash/2015/webprogramscheduler/start.html)
Abstracts of the 58th Annual Meeting of the American Society of Hematology; 2016 Dec 3-6; San Diego, California (searched online at htpps://ash.confex.com/ash/2016/webprogram/start.html)
Abstracts of the 59th Annual Meeting of the American Society of Hematology; 2017 Dec 9-12; Atlanta, Georgia (Blood 2017, Vol. 130 Suppl 1)
Abstracts of the 60th Annual Meeting of the American Society of Hematology; 2018 Dec 1-4; San Diego, California (Blood 2018, Vol. 132 Suppl 1)
British Society for Haematology
British Society for Haematology Annual Scientific Meeting; 1995 April 3‐6; Brighton (British Journal of Haematology 1995, Vol. 89, Suppl. 1)
British Society for Haematology Annual Scientific Meeting; 1996 April 22‐25; Birmingham (British Journal of Haematology 1996, Vol. 93, Suppl. 1)
British Society for Haematology 39th Annual Scientific Meeting; 1999 April 12‐15; Brighton (British Journal of Haematology 1999, Vol. 105, Suppl. 1)
British Society for Haematology 40th Annual Scientific Meeting; 2000 March 27‐29; Bournemouth (British Journal of Haematology 2000, Vol. 108, Suppl. 1)
British Society for Haematology 41st Annual Scientific Meeting; 2001 April 23‐26; Harrogate (British Journal of Haematology 2001, Vol. 113, Suppl. 1)
British Society for Haematology 42nd Annual Scientific Meeting; 2002 April 15‐18; Brighton (British Journal of Haematology 2002, Vol. 117, Suppl. 1)
British Society for Haematology 43rd Annual Scientific Meeting; 2003 April 7‐9; Glasgow (British Journal of Haematology 2003, Vol. 121, Suppl. 1)
British Society for Haematology 44th Annual Scientific Meeting; 2004 April 19‐21; Cardiff, UK (British Journal of Haematology 2004, Vol. 125, Suppl. 1)
British Society for Haematology 45th Annual Scientific Meeting; 2005 April 11‐13; Manchester, UK (British Journal of Haematology 2005, Vol. 129, Suppl. 1)
British Society for Haematology 46th Annual Scientific Meeting; 2006 April 3‐5; Edinburgh, UK (British Journal of Haematology 2006, Vol. 133, Suppl. 1)
British Society for Haematology 47th Annual Scientific Meeting; 2007 April 30‐ May 2; Bournemouth, UK (British Journal of Haematology 2007, Vol. 137, Suppl. 1)
British Society for Haematology 48th Annual Scientific Meeting; 2008 April 7‐9; Glasgow, UK (British Journal of Haematology 2008, Vol. 141, Suppl. 1)
British Society for Haematology 49th Annual Scientific Meeting; 2009 April 27‐29; Brighton, UK (British Journal of Haematology 2009, Vol. 145, Suppl. 1)
British Society for Haematology 50th Annual Scientific Meeting; 2010 April 19?21; Edinburgh, UK (British Journal of Haematology 2010, Vol. 149, Suppl. 1)
British Society for Haematology 51st Annual Scientific Meeting; 2011 April 4?6; Brighton, UK (British Journal of Haematology 2011, Vol. 153, Suppl. 1)
British Society for Haematology 52nd Annual Scientific Meeting; 2012 April 16‐18; Glasgow, UK (British Journal of Haematology 2012, Vol. 157, Suppl. 1)
British Society for Haematology 53rd Annual Scientific Meeting; 2013 April 15‐17; Liverpool, UK (British Journal of Haematology 2013, Vol. 161, Suppl. 1)
British Society for Haematology 54th Annual Scientific Meeting, 2014 April 28‐30; Birmingham, UK (British Journal of Haematology 2014, Vol. 165, Suppl. 1)
British Society for Haematology 55th Annual Scientific Meeting, 2015 April 20-22; Edinburgh, UK (British Journal of Haematology 2015, Vol. 169, Suppl. 1)
British Society for Haematology 56th Annual Scientific Meeting, 2016 April 18-21; Glasgow, UK (British Journal of Haematology 2016, Vol. 173, Suppl. 1)
British Society for Haematology 57th Annual Scientific Meeting, 2017 March 27-29; Brighton, UK (British Journal of Haematology 2017, Vol. 176, Suppl. 1)
British Society for Haematology 58th Annual Scientific Meeting, 2018 April 16-18; Liverpool, UK (British Journal of Haematology 2018, Vol. 181, Suppl. 1)
Congress Of The World Federation of Haemophilia
Congress of the World Federation of Haemophilia; 1996 June 23‐28; Dublin, Ireland (Haemophilia 1996, Vol. 2, Suppl. 1)
Congress of the World Federation of Haemophilia; 1998 May 17‐21; The Hague, Netherlands (Haemophilia 1998, Vol. 4, Issue 3)
Congress of the World Federation of Haemophilia; 2000 July 16‐21; Montreal, Canada (Haemophilia 2000, Vol. 6, Issue 4)
Congress of the World Federation of Haemophilia; 2002 May 19‐24; Seville, Spain (Haemophilia 2002, Vol. 8, Issue 4)
Congress of the World Federation of Haemophilia; 2004 Oct 17‐21; Bangkok, Thailand (Haemophilia 2004, Vol. 10, Suppl 3 and Suppl 4)
Congress of the World Federation of Haemophilia; 2006 May 21‐25; Vancouver, Canada (Haemophilia 2006, Vol. 12, Suppl¬2)
(No meeting 2007)
Congress of the World Federation of Haemophilia; 2008 Jun 1‐5; Istanbul, Turkey (Haemophilia 2008, Vol 14, Suppl 2)
(No meeting 2009)
Congress of the World Federation of Haemophilia; 2010 July 10‐14; Buenos Aires, Argentina (Haemophilia 2010, Vol 16, Suppl 4)
(No meeting 2011)
Congress of the World Federation of Haemophilia; 2012 July 8‐12; Paris, France (Haemophilia 2012, Vol 18, Suppl 3)
(No meeting 2013)
Congress of the World Federation of Haemophilia; 2014 May 11‐15; Melbourne, Australia (Haemophilia 2014, Vol 20, Suppl 3)
(No meeting 2015)
Congress of the World Federation of Haemophilia; 2016 July 24-28; Orlando, Florida (Haemophilia 2016, Vol. 22, Suppl 5)
(No meeting 2017)
Congress of the World Federation of Haemophilia; 2018 May 20-24; Glasgow, Scotland (Haemophilia 2018, Vol. 25, Suppl 5)
The International Society on Thrombosis and Haemostasis
XXI ISTH Congress Abstracts (2007)
XXII ISTH Congress Abstracts (2009)
XXIII ISTH Congress Abstracts (2011)
58th Annual SSC Meeting Abstracts (2012)
XXIV ISTH Congress Abstracts (2013)
60th Annual SSC Meeting Abstracts (2014)
XXV ISTH Congress Abstracts (2015)
62nd Annual SSC Meeting Abstracts (2016)
XXVI ISTH Congress Abstracts (2017)
European Association for Haemophilia and Allied Disorders
6th Annual Congress of the European Association for Haemophilia and Allied Disorders, 2013 February 6‐8, Warsaw, Poland
7th Annual Congress of the European Association for Haemophilia and Allied Disorders, 2014 February 26‐28, Brussels, Belgium
8th Annual Congress of the European Association for Haemophilia and Allied Disorders, 2015 February 11‐13, Helsinki, Finland
9th Annual Congress of the European Association for Haemophilia and Allied Disorders, 2016 February 3-5, Malmo, Sweden
10th Annual Congress of the European Association for Haemophilia and Allied Disorders, 2017 February 1-2, Paris, France
11th Annual Congress of the European Association for Haemophilia and Allied Disorders, 2018 February 7-9 Madrid, Spain
Hemostasis and Thrombosis Research Society
Scientific Symposium of the Hemostasis and Thrombosis Research Society; April 16-18, 2015, New Orleans, Louisiana (Haemophilia 2015, Vol 21, e260-e280) 3)
Scientific Symposium of the Hemostasis and Thrombosis Research Society; April 6-8, 2017, Scottsdale, Arizona (Haemophilia 2017, Vol 23, Suppl 3)