We previously produced systematic reviews of interventions relating to the care of people of with a number of genetic disorders (as described below) and to their families. As well as interventions aimed at preventing or treating genetic disorders, measures for early detection are particularly relevant to those with inherited diseases. Our reviews only included evidence from randomised controlled trials (RCTs) and the Group’s previous broad areas of interest are listed below.

Cystic Fibrosis	Haemoglobinopathies
All interventions covering the early detection and ongoing treatment of cystic fibrosis.	All interventions concerned with the early detection and treatment of haemoglobinopathies (e.g. sickle cell disease and thalassaemias).
Inborn errors of metabolism	Inherited coagulopathies
All interventions concerned with the early detection and treatment of inborn errors of metabolism (e.g. Gaucher's disease, phenylketonuria, galactosaemia).	All interventions concerned with the early detection and treatment of inherited coagulopathies (e.g. haemophilia).
Other genetic disorders We also considered reviews of other genetic disorders which did not clearly fall into these areas on a case-by-case basis by the editorial team. We published a number of so-called 'orphan' reviews where our decisions depended on whether the review might be more appropriately placed in another registered or emerging group and an analysis of the time required.